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SELECTED PAST STUDIES - Central Nervous System Diseases - Parkinson's Disease

Study

Disease

type & number of samples

Specific Requirements

associated data required

PD-1

Parkinson’s Disease

Cerebrospinal Fluid

Retrospective

More than 30 subjects

3 groups:

  • Parkinson’s Disease without dementia
  • Parkinson’s Disease with dementia
  • Age-matched Control s(“healthy”)
  • Subjects with confirmed Alzheimer’s Disease are excluded
  • Age, Gender, Ethnicity
  • Sample collection date
  • Date of diagnosis
  • Treatment and medical history

PD-2

Parkinson’s Disease

Brain Frozen Tissue

Retrospective

More than 5 subjects

2 groups:

  • Parkinson’s Disease
  • Age-matched control (“healthy”)
  • Brain Temporal Cortical Frozen tissue
  • All samples have histologically confirmed Lewy Body pathology
  • Age, Gender, Ethnicity
  • Clinical and neuropathological diagnosis
  • Clinical History
  • PMI

PD-3

Parkinson’s Disease

Brain FFPE Slides

Retrospective

More than 150 subjects

  • Subjects with leucine-rich repeat kinase 2 (LRRK2) G2019S mutation
  • Brain Tissue Sub-Regions:
    • Dorsolateral Prefrontal Cortex
    • Dorsolateral Amygdala
    • Dorsolateral Putamen
  • Age, Gender, Ethnicity
  • Clinical and neuropathological diagnosis