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SELECTED PAST STUDIES - Central Nervous System Diseases - Alzheimer's Disease

Study

Disease

type & number of samples

Specific Requirements

associated data required

AD-1

Alzheimer’s Disease

Serum

Retrospective

More than 200 subjects

7 Groups:

  • Mild AD, Moderate AD
  • Mild Cognitive Disorder (MCI) (“AD Converter”)
  • Mild Cognitive Disorder (“Stable MCI”)
  • Lewy Body Dementia
  • Frontotemporal Dementia
  • Vascular Dementia
  • Healthy Controls Retrospective
  • Serum
  • All demographic, and medical data 
  • MMSE and MOCA, scores 
  • CSF Amyloid-ß42, t-Tau, and p-Tau concentrations

AD-2

Alzheimer’s Disease

Plasma

Prospective

More than 100 subjects

4 Groups:

  • Alzheimer’s Disease
  • Frontal Temporal Lobe Dementia
  • Dementia with Lewy Bodies
  • Controls Prospective
  • EDTA plasma 
  • All demographic, and medical data
  • Imaging (PET Scan, MRI) • Cerebrospinal Fluid Tau levels

AD-3

Alzheimer’s Disease

Cerebrospinal Fluid

Retrospective

More than 300 subjects

Different CSF hTau A:

  • 1-42 spanning the entire clinical range Retrospective

 

  • Cerebrospinal fluid samples collected with strictly standardized protocol
  • All demographic, and medical data • MMSE score

AD-4

Alzheimer’s Disease

Frozen Brain Tissue

Retrospective

More than 15 subjects

  • Different pattern for density of alpha-synuclein, tau and amyloid Retrospective
  •  Frozen brain cortical tissue
  • All demographic, and medical data
  • MMSE
  • Braak Stage
  • Neuropathology report

AD-5

Alzheimer’s Disease

Frozen Brain Tissue

Retrospective

More than 40 subjects:

  • Alzheimer’s Disease and age- and gender-matched controls
  • Frozen brain frontal cortical tissue
  • All demographic, and medical data
  • MMSE
  • Braak Stage
  • Neuropathology report