Home > Selected Past Studies

SELECTED PAST STUDIES - Central Nervous System Diseases

Study

Disease

type & number of samples

Specific Requirements

associated data required

AD-1

Alzheimer’s Disease

Serum

Retrospective

More than 200 subjects

7 Groups:

  • Mild AD, Moderate AD
  • Mild Cognitive Disorder (MCI) (“AD Converter”)
  • Mild Cognitive Disorder (“Stable MCI”)
  • Lewy Body Dementia
  • Frontotemporal Dementia
  • Vascular Dementia
  • Healthy Controls Retrospective
  • Serum
  • All demographic, and medical data 
  • MMSE and MOCA, scores 
  • CSF Amyloid-ß42, t-Tau, and p-Tau concentrations

AD-2

Alzheimer’s Disease

Plasma

Prospective

More than 100 subjects

4 Groups:

  • Alzheimer’s Disease
  • Frontal Temporal Lobe Dementia
  • Dementia with Lewy Bodies
  • Controls Prospective
  • EDTA plasma 
  • All demographic, and medical data
  • Imaging (PET Scan, MRI) • Cerebrospinal Fluid Tau levels

AD-3

Alzheimer’s Disease

Cerebrospinal Fluid

Retrospective

More than 300 subjects

Different CSF hTau A:

  • 1-42 spanning the entire clinical range Retrospective

 

  • Cerebrospinal fluid samples collected with strictly standardized protocol
  • All demographic, and medical data • MMSE score

AD-4

Alzheimer’s Disease

Frozen Brain Tissue

Retrospective

More than 15 subjects

  • Different pattern for density of alpha-synuclein, tau and amyloid Retrospective
  •  Frozen brain cortical tissue
  • All demographic, and medical data
  • MMSE
  • Braak Stage
  • Neuropathology report

AD-5

Alzheimer’s Disease

Frozen Brain Tissue

Retrospective

More than 40 subjects:

  • Alzheimer’s Disease and age- and gender-matched controls
  • Frozen brain frontal cortical tissue
  • All demographic, and medical data
  • MMSE
  • Braak Stage
  • Neuropathology report

PD-1

Parkinson’s Disease

Cerebrospinal Fluid

Retrospective

More than 30 subjects

3 groups:

  • Parkinson’s Disease without dementia
  • Parkinson’s Disease with dementia
  • Age-matched Control s(“healthy”)
  • Subjects with confirmed Alzheimer’s Disease are excluded
  • Age, Gender, Ethnicity
  • Sample collection date
  • Date of diagnosis
  • Treatment and medical history

PD-2

Parkinson’s Disease

Brain Frozen Tissue

Retrospective

More than 5 subjects

2 groups:

  • Parkinson’s Disease
  • Age-matched control (“healthy”)
  • Brain Temporal Cortical Frozen tissue
  • All samples have histologically confirmed Lewy Body pathology
  • Age, Gender, Ethnicity
  • Clinical and neuropathological diagnosis
  • Clinical History
  • PMI

PD-3

Parkinson’s Disease

Brain FFPE Slides

Retrospective

More than 150 subjects

  • Subjects with leucine-rich repeat kinase 2 (LRRK2) G2019S mutation
  • Brain Tissue Sub-Regions:
    • Dorsolateral Prefrontal Cortex
    • Dorsolateral Amygdala
    • Dorsolateral Putamen
  • Age, Gender, Ethnicity
  • Clinical and neuropathological diagnosis

TBI-1

Traumatic Brain Injury

Plasma

Prospective

More than 250 subjects

  • Glasgow Coma Scale Score between 3 to 15
  • Up to 4 samples collected per subject at different time points after head injury within:
    • 0-3 hours
    • 8-12 hours
    • 24-48 hours
    • 48-72 hours
  • Age, Gender, Ethnicity
  • Date/Time of initial presentation or injury
  • Cause of TBI
  • Other traumatic injuries
  • Date/Time of blood collection
  • GCS score at admission

MS-1

Multiple Sclerosis

Plasma

Retrospective

More than 30 subjects

2 groups:

  • Patients who had an attack within 12 months after treatment initiation
  • Patients without an additional attack and without significant (over 5) new T1/FLAIR lesions in the brain
  • Treated subjects only
  • Age, gender, ethnicity
  • Duration of the disease

MS-2

Multiple Sclerosis

Frozen Brain Tissue

Retrospective

More than 2 subjects

  • Brain tissue regions:
    • Occipital Cortex
    • Cerebellum
    • Pons
    • Temporal Lobe
    • Basal Ganglia
    • Parietal Lobe
    • Frontal Cortex
    • White Matter
    • Cervical Cord
  • Age, gender, ethnicity
  • Duration of the disease
  • PMI