Home > Selected Past Studies

SELECTED PAST STUDIES - Immune Disorders & Other Diseases

Study

Disease

type & number of samples

Specific Requirements

associated data required

RA-1

Rheumatoid Arthritis

Serum

Retrospective

More than 70 subjects

  • Diagnosis of RA more than 1 year
  • Collections at multiple time points including baseline, and multiple serial collections for a minimum of 2yrs
  • Age, gender, ethnicity
  • Disease activity assessment (DAS28)
  • Health assessment questionnaire
  • Radiographic assessment (VdH Score)
  • CRP, CCP, and RF

RA-2

Rheumatoid Arthritis

Serum

Prospective

More than 200 subjects

4 groups:

  • Rheumatoid Arthritis
  • Psoriatic Arthritis
  • Ankylosing Spondylitis
  • Dermatomyositis
  • Several aliquots
  • Age, gender, ethnicity
  • Medical history
  • Treatment history
  • Clinical outcome

PS-1

Psoriasis

Fresh Skin Biopsies

Prospective

More than 20 subjects

  • 3 biopsies per subject from inflamed site
  • Samples shipped immediately after collection at 4°C
  • Age, gender, ethnicity
  • Clinical history
  • Concomitant treatment

PS-2

Psoriasis

Skin FFPE

Retrospective

More than 20 subjects

2 groups:

  • Psoriasis
  • Hidradenitis
  • Skin Fistulae, Sinus or Fissure tissue blocks
  • Fistulising/Sinus-Forming Dermatological Disease
  • Age, gender, ethnicity
  • Concurrent therapies known, including date of last anti-TNF dose

CD-1

Crohn’s Disease

Frozen Intestinal Tissue

Prospective

More than 30 Subjects

  • For each subject: Resections or biopsies of fibrotic tissues and of normal adjacent tissue
  • Age, gender, ethnicity
  • Clinical history
  • Clinical data regarding IBD

CD-2

Crohn’s Disease

Peripheral Blood Mononuclear Cells

Retrospective

More than 24 subjects:

3 groups:

  • Crohn’s Disease
  • Ulcerative Colitis
  • Matched Healthy Controls
  • PBMCs from subjects with active disease and/or in remission
  • Age, gender, ethnicity
  • Date of collection
  • Disease activity at time of collection
  • Treatment history

LE-1

Systemic Lupus Erythematosus

Kidney FFPE Tissue Blocks

Retrospective

More than 30 subjects with Lupus Nephritis

3 groups:

  • No interstitial inflammation
  • Mild interstitial inflammation
  • Moderate/severe interstitial inflammation
  • Kidney biospecimen (biopsies and/or samples from autopsy)
  • Specimen collected within 2 years of initial diagnosis of SLE
  • Age, gender, ethnicity
  • Clinical diagnosis
  • WHO classification for SLE
  • Age of patient at biopsy or sample collection
  • Pathology report

LE-2

Systemic Lupus Erythematosus

Plasma and matched Urine

Prospective

More than 50 subjects

3 groups:

  • SLE
  • Lupus nephritis
  • Matched Healthy controls
  • Subjects diagnosed with SLE with SLE Disease Activity Index (SLEDAI) > 6 and anti-nuclear antibodies (ANA) > 80
  • Subjects diagnosed with LN by biopsy
  • Age, gender, ethnicity
  • Confirmation of diagnosis

SS-1

Primary Sjögren’s Syndrome

Saliva and Tears

Prospective

More than 50

6 subjects

2 groups:

  •  Local and systemic Primary Sjögren’s Syndrome
  • Matched control subjects
  • Whole saliva and parotid saliva
  • Moderate, stable disease
  • Tears collected using Schirmer strips
  • Age, gender, ethnicity
  • Medication
  • Clinical data

TR-1

Heart and Renal Transplant Rejection

RNA and Plasma

Prospective

More than 80 Subjects

4 groups:

  • Acute heart rejection as confirmed by endomyocardial biopsy
  • No heart rejection as confirmed by endomyocardial biopsy
  • Acute kidney rejection as confirmed by kidney biopsy with a Banff grade > 1
  • No kidney rejection as confirmed by kidney biopsy
  • Frozen EDTA Plasma and Isolated RNA
  • Age, gender, ethnicity
  • Treatment history
  • Time duration between post-transplant biopsy and blood sample collection

CLD-1

Celiac Disease

Serum

Retrospective

More than 120 subjects

  • Celiac Disease (non gluten-free diet, biopsy positive)
  • Age, gender, ethnicity
  • Clinical diagnosis of Celiac Disease biopsy report
  • Serological test results

AL-1

Allergy

Serum

Retrospective

More than 25 subjects

  • Tomato Lyc e 2 allergen
  • Age, gender, ethnicity
  • IgE

OD-1

Atopic Dermatitis

Fresh Skin Tissues

Retrospective

More than 10 subjects

  • Skin punch biopsies
  • A diagnosis with moderate to severe AD
  • Samples delivered in tissue culture media within 24 hours at +4°C
  • Age, gender, ethnicity
  • Concurrent disorders
  • Date of sample collection
  • Medical treatment history

OD-2

Diabetes Mellitus

Frozen Liver and Spleen tissues

Retrospective

More than 15 subjects

2 groups:

  •  Diabetes Type I
  • Control, non-diabetic, subjects
  • Subjects between 30 to 65 years
  • Age, gender, ethnicity
  • Weight
  • Medical history

OD-3

Progressive Supranuclear Palsy

Frozen Brain Tissue

Retrospective

More than 2 subjects

  • Caudate Nucleus
  •  Putamen
  • Globus Pallidus
  • Diagnosis of PSP confirmed by immunohistochemistry using anti-tau antibodies
  • Age, gender, ethnicity
  • Medical history
  • Confirmed diagnosis (anti-Tau ICH results)
  • PMI

OD-4

Barrett's Esophagus

Esophagus FFPE Tissue Blocks

Retrospective

More than 15 subjects

  • Esophagus tissue
  • Tissue from resections or biopsies
  • Age, gender, ethnicity
  • Medical history
  • Treatment history

OD-5

Idiopathic Pulmonary Fibrosis

FFPE and Frozen Lung Tissue Blocks and Serum

Prospective

More than 18 subjects

  • Lung tissues samples from resections, biopsies, or autopsy
  • IPF diagnosed with lung biopsy and/or High Resolution Computed Tomography (HCRT)
  • Age, gender, ethnicity
  • Pathology report
  • Clinical Diagnosis method (e.g. HCRT or biopsy/autopsy)
  • Medical history
  • Treatment history

OD-6

Fatty Liver or Non- Alcoholic Steatohepatitis

Liver FFPE slides and Plasma

Retrospective

More than 20 subjects 

2 groups:

  • NASH with mild fibrosis
  • NASH with moderate fibrosis
  • NAFLD fibrosis score
  • Age, gender, ethnicity
  • Duration of the disease
  • Medical history

OD-7

Hypertrophic Cardiomyopathy

Whole Blood

Prospective

More than 200 subjects

  • Diagnosed with Hypertrophic Cardiomyopathy
  • Age, gender, ethnicity
  • Treatment history
  • Disease-causing genetic mutation information